Resveratrol

Key points

• Resveratrol activates SIRT1 (sirtuin 1) — the enzyme that orchestrates cellular stress response, fat metabolism, and DNA repair
• The "xenohormesis" hypothesis: resveratrol is a stress signal from plants that triggers survival pathways in mammals consuming them
• Must be taken with fat — resveratrol is fat-soluble and has near-zero oral bioavailability without it
• Sinclair takes 1g with yoghurt in the morning; do not take with excessive quercetin (competes for the same pathway)
• Evidence in humans is weaker than in animal models — works best as part of a broader lifestyle protocol