NMN (Nicotinamide Mononucleotide)

Key points

• NAD+ is essential for sirtuin activation, DNA repair, and mitochondrial function — all decline ~50% by age 50
• NMN converts to NMN inside cells and then to NAD+ — it is taken up directly via NMN transporters (Slc12a8)
• Sinclair takes 1g NMN every morning — alongside resveratrol with fat for activation
• Human RCT data is still limited; animal data is very strong — this is an educated bet, not proven medicine
• Sublingual or powder form may improve absorption over standard capsules