Curcumin + Piperine

Key points

• Curcumin is the active polyphenol in turmeric — raw turmeric has only ~3% curcumin by weight
• Piperine (black pepper extract) inhibits CYP3A4, the liver enzyme that rapidly clears curcumin — increases bioavailability 20×
• 95% curcuminoids standardised extract is the therapeutic form used in research
• Reduces NF-κB, COX-2, and IL-6 — the core inflammatory signalling pathways in RA and joint disease
• Huberman caution: high doses may blunt the adaptive response to resistance training — take timing into account on training days