Alpha-GPC (Choline)

Key points

• Alpha-GPC crosses the blood-brain barrier and rapidly raises acetylcholine — the neurotransmitter of focus, memory formation, and muscle contraction
• Huberman takes 300mg before training — improves power output and mind-muscle connection
• Stacks well with caffeine — the combination is more effective than either alone for cognitive performance
• Ongoing concern about TMAO (trimethylamine N-oxide) formation with long-term high doses — cycle or use periodically
• 300–600mg is the studied range; take 30–60 minutes before the activity requiring focus